https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43455 p < 0.001); whilst those with an unhealthy diet and no MVM or fish oil consumption were associated with a higher risk of obesity (p < 0.05). Compared to participants with a long-term healthy diet and no calcium consumption, the combination of a long-term healthy diet and calcium consumption was linked to a lower risk of CVD (IRR = 0.87, 95% CI: 0.78; 0.96). In conclusion, a long-term healthy diet combined with MVM or fish oil was associated with a lower incidence of CVD. Participants who maintained a healthy diet and used calcium supplements were associated with a lower incidence of obesity. However, these associations were not found among those with an unhealthy diet, despite taking similar supplements.]]> Wed 28 Sep 2022 14:35:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45076 ELN gene expression in tumors from CRC patients and adjacent non-tumor colon tissues and healthy controls from two existing microarray datasets. ELN protein was measured in human normal colon cells and colon cancer epithelial cells and tumor development was assessed in colon epithelial cells cultured in medium with or without ELN peptide on plates coated with ELN recombinant protein. Control plates were coated with PBS only. Results: We found ELN gene expression was increased in tumors from CRC patients compared to adjacent non-tumor tissues and healthy controls. ELN protein was increased in cancer cells compared to normal colon epithelial cells. Transforming growth factor beta (TGF-β) was a key cytokine to induce production of ECM proteins, but it did not induce ELN expression in colon cancer cells. Matrix metalloproteinase 9 (MMP9) gene expression was increased, but that of MMP12 (elastase) did not change between CRC patients and control. Tissue inhibitor of metalloproteinases 3 (TIMP3) gene expression was decreased in colon tissues from CRC patients compared to healthy controls. However, MMP9, MMP12 and TIMP3 proteins were increased in colon cancer cells. ELN recombinant protein increased proliferation and wound healing in colon cancer epithelial cells. This had further increased in cancer cells incubated in plates coated with recombinant ELN coated plate and in culture media containing ELN peptide. A potential mechanism was that ELN induced epithelial mesenchymal transition with increased alpha-smooth muscle actin and vimentin proteins but decreased E-cadherin protein. Tumor necrosis factor alpha (TNF) mRNA was also increased in CRC patients compared to controls. ELN recombinant protein induced further increases in TNF protein in mouse bone marrow derived macrophages after lipopolysaccharide stimulation. Conclusions: These data suggest ELN regulates tumor development and the microenvironment in CRC.]]> Wed 26 Oct 2022 12:30:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27866 Wed 24 Nov 2021 15:53:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36901 Wed 15 Jul 2020 19:31:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27584 Wed 11 Apr 2018 17:16:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22739 Wed 11 Apr 2018 13:28:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17465 Wed 11 Apr 2018 12:20:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22995 Wed 11 Apr 2018 11:28:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17386 Wed 11 Apr 2018 09:59:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29961 Wed 11 Apr 2018 09:38:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36984 Wed 10 Nov 2021 15:12:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35749 Tue 10 Oct 2023 13:55:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43873 Tue 04 Oct 2022 12:29:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30655 Tue 03 Sep 2019 18:30:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35753 Thu 28 Nov 2019 12:41:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31325 Thu 24 Mar 2022 11:35:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30977 0.05) in CRP and serum ferritin across quartiles for either dietary pattern. In the fully adjusted model, the prevalence ratio (PR) of anaemia, comparing the fourth quartile to the first quartile, was 1.75 (95% CI: 1.33; 2.29) for a traditional dietary pattern, and 0.89 (95% CI: 0.68; 1.16) for a modern dietary pattern. The association between dietary patterns and anaemia is mediated by serum magnesium. Conclusion: Traditional dietary pattern is associated with a higher prevalence of anaemia among older Chinese. Future studies need to examine whether correcting micronutrient deficiency (e.g. magnesium) by promoting overall healthy diet, rather than iron supplementation, is a suitable strategy for anaemia prevention in older Chinese people.]]> Thu 21 Oct 2021 12:51:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32037 Thu 09 Dec 2021 11:02:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27863 Sat 24 Mar 2018 07:41:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30975 Sat 24 Mar 2018 07:27:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42353 Mon 22 Aug 2022 14:01:26 AEST ]]>